Entropy, as a complexity measure, is a fundamental concept for time series analysis. Among many methods, sample entropy\r\n(SampEn) has emerged as a robust, powerful measure for quantifying complexity of time series due to its insensitivity to data\r\nlength and its immunity to noise. Despite its popular use, SampEn is based on the standardized data where the variance is\r\nroutinely discarded, which may nonetheless provide additional information for discriminant analysis. Here we designed a simple,\r\nyet efficient, complexity measure, namely variance entropy (VarEn), to integrate SampEn with variance to achieve effective\r\ndiscriminant analysis. We applied VarEn to analyze local field potential (LFP) collected from visual cortex of macaque monkey\r\nwhile performing a generalized flash suppression task, in which a visual stimulus was dissociated from perceptual experience, to\r\nstudy neural complexity of perceptual awareness. We evaluated the performance of VarEn in comparison with SampEn on LFP,\r\nat both single and multiple scales, in discriminating different perceptual conditions. Our results showed that perceptual visibility\r\ncould be differentiated by VarEn, with significantly better discriminative performance than SampEn. Our findings demonstrate\r\nthat VarEn is a sensitive measure of perceptual visibility, and thus can be used to probe perceptual awareness of a stimulus.
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